Dose optimization of ceftriaxone-vancomycin combination using fractional inhibitory concentration kinetics in resistant bacteria
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چکیده
منابع مشابه
Dose optimization of ceftriaxone-vancomycin combination using fractional inhibitory concentration kinetics in resistant bacteria
The notorious Staphylococcus aureus resistant strains with ever changing resistance patterns have limited treatment options and have led to substantial number of deaths. Almost dried antibiotic pipeline has led us to look into combinations of already approved antibiotics for tackling rising incidence of antibacterial resistance. Recommended use of vancomycin and ceftriaxone together for treatin...
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Combination therapy with antimicrobial agents can be used against bacteria that have reduced susceptibilities to single agents. We studied various tobramycin and ceftazidime dosing regimens against four resistant Pseudomonas aeruginosa strains in an in vitro pharmacokinetic model to determine the usability of combination therapy for the treatment of infections due to resistant bacterial strains...
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Antibiotics are highly successful in controlling bacterial infection but they have many toxic effects, sometimes very fatal. Aim of the present study was to evaluate subchronic toxicity of fixed dose combination of ceftriaxone-vancomycin in mice. Male and female mice were divided into four groups depending on dose of ceftraixone-vancomycin (0, 10, 100 and 500 mg/kg i.m.). Hematological, biochem...
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Background&Aims: Vancomycin Resistant Enterococci (VRE) are among the most common nosocomial pathogens worldwide. The intestinal tract provides a major source for transmission of these bacteria. Probiotics are living microorganisms that moderate use of them has inhibitory effect on intestinal colonization by enteric pathogens. We examined the effect of Lactobacillus rhamnosus GG (LGG) on inhibi...
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ژورنال
عنوان ژورنال: ADMET and DMPK
سال: 2016
ISSN: 1848-7718
DOI: 10.5599/admet.4.3.286